Aggressive Central Giant Cell Granuloma in a Child: A Case Report and Review

Introduction: An aggressive variant of central giant cell granuloma in a paediatric patient is a localized benign osteolytic prolif- eration. The lesion consist of fibrous tissue with haemorrhage, hemosiderin deposits and presence of osteoclast-like giant cells with reactive bone formation. Clinically shown with rapid growth, resorption of roots, displacement of teeth and thinning or perforation of cortical bone, and marked recurrence. Case presentation: A 9-year-old boy reported with a 3 days history of asymptomatic soft tissue swelling in left mandibular pos- terior region which was diagnosed as central giant cell granuloma based on clinical, radiological and histopathological features. Management and Prognosis: Surgical resection was performed without any signs of recurrence on 9 months follow up. Conclusion: Prompt diagnosis and treatment of Central giant cell granuloma can significantly improve morbidity and long- term outcomes.

Process optimization of efavirenz film coated tablet.

Optimization is often used in pharmacy relative to formulation & processing and one may find it in literature referring to any study of formula. Optimize means to make a perfect, effective (or) functional as possible. Process optimization is the discipline of adjusting a process so as to optimize some specified set of parameters without violating some constraint. The most common goals are minimizing cost, maximizing output, and/or efficiency. This is one of major quantitative tools in industrial decision making. In the present work process parameters at developmental stages of formulation were studied extensively and after completion of the data generated during the Process Optimization of Efavirenz tablets , some critical parameters were identified and some changes are recommended in various stages of manufacturing process and finally proved that process is capable of producing a drug of required quality with proposed process.